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1

Beyond Antibodies: The DARPinÂ® Drug Platform

Stumpp, Michael T., Dawson, Keith M., Binz, H. Kaspar

Journal:

Year:

2020

File:

PDF, 1.20 MB

2020

2

Folding of a designed simple ankyrin repeat protein

V. Sathya Devi, H. Kaspar Binz, Michael T. Stumpp, Andreas Plückthun, Hans Rudolf Bosshard, Ilian Jelesarov

Journal:

Protein Science

Year:

2004

Language:

english

File:

PDF, 126 KB

english, 2004

3

Crystal structure of a consensus-designed ankyrin repeat protein: Implications for stability

H. Kaspar Binz, Andreas Kohl, Andreas Plückthun, Markus G. Grütter

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2006

Language:

english

File:

PDF, 706 KB

english, 2006

4

Folding and Unfolding Mechanism of Highly Stable Full-Consensus Ankyrin Repeat Proteins

Svava K. Wetzel, Giovanni Settanni, Manca Kenig, H. Kaspar Binz, Andreas Plückthun

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.27 MB

english, 2008

5

Allosteric Inhibition of Aminoglycoside Phosphotransferase by a Designed Ankyrin Repeat Protein

Andreas Kohl, Patrick Amstutz, Petra Parizek, H. Kaspar Binz, Christophe Briand, Guido Capitani, Patrik Forrer, Andreas Plückthun, Markus G. Grütter

Journal:

Year:

2005

Language:

english

File:

PDF, 702 KB

english, 2005

6

Engineering novel binding proteins from nonimmunoglobulin domains

Binz, H Kaspar, Amstutz, Patrick, Plückthun, Andreas

Journal:

Nature Biotechnology

Year:

2005

Language:

english

File:

PDF, 633 KB

english, 2005

7

Half-life extension using serum albumin-binding DARPin® domains

Steiner, Daniel, Merz, Frieder W, Sonderegger, Ivo, Gulotti-Georgieva, Maya, Villemagne, Denis, Phillips, Douglas J, Forrer, Patrik, Stumpp, Michael T, Zitt, Christof, Binz, H Kaspar

Journal:

Protein Engineering Design and Selection

Year:

2017

Language:

english

File:

PDF, 721 KB

english, 2017

8

Molecular dynamics study of the stabilities of consensus designed ankyrin repeat proteins

Haibo Yu, Andreas Kohl, H. Kaspar Binz, Andreas Plückthun, Markus G. Grütter, Wilfred F. van Gunsteren

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2006

Language:

english

File:

PDF, 1.19 MB

english, 2006

9

Designing Repeat Proteins: Well-expressed, Soluble and Stable Proteins from Combinatorial Libraries of Consensus Ankyrin Repeat Proteins

H.Kaspar Binz, Michael T Stumpp, Patrik Forrer, Patrick Amstutz, Andreas Plückthun

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 1.80 MB

english, 2003

10

Cover Picture: Consensus Design of Repeat Proteins (ChemBioChem 2/2004)

Patrik Forrer, H. Kaspar Binz, Michael T. Stumpp, Andreas Plückthun

Journal:

Year:

2004

File:

PDF, 19 KB

2004

11

Designing Repeat Proteins: Modular Leucine-rich Repeat Protein Libraries Based on the Mammalian Ribonuclease Inhibitor Family

Michael T. Stumpp, Patrik Forrer, H.Kaspar Binz, Andreas Plückthun

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 2.57 MB

english, 2003

12

High-affinity binders selected from designed ankyrin repeat protein libraries

Binz, H Kaspar, Amstutz, Patrick, Kohl, Andreas, Stumpp, Michael T, Briand, Christophe, Forrer, Patrik, Grütter, Markus G, Plückthun, Andreas

Journal:

Nature Biotechnology

Year:

2004

Language:

english

File:

PDF, 1.53 MB

english, 2004

13

Consensus Design of Repeat Proteins

Patrik Forrer, H. Kaspar Binz, Michael T. Stumpp, Andreas Plückthun

Journal:

Year:

2004

Language:

english

File:

PDF, 192 KB

english, 2004

14

Characterization of a drug-targetable allosteric site regulating vascular endothelial growth factor signaling

Thieltges, Katherine M., Avramovic, Dragana, Piscitelli, Chayne L., Markovic-Mueller, Sandra, Binz, Hans Kaspar, Ballmer-Hofer, Kurt

Journal:

Year:

2018

Language:

english

File:

PDF, 1.78 MB

english, 2018

15

Mutational analysis of the interaction between albumin-binding domain from streptococcal protein G and human serum albumin

Martin Linhult, Hans Kaspar Binz, Mathias Uhlén, Sophia Hober

Journal:

Protein Science

Year:

2002

Language:

english

File:

PDF, 319 KB

english, 2002

16

Design and characterization of MP0250, a tri-specific anti-HGF/anti-VEGF DARPin® drug candidate

Binz, H. Kaspar, Bakker, Talitha R., Phillips, Douglas J., Cornelius, Andreas, Zitt, Christof, Göttler, Thomas, Sigrist, Gabriel, Fiedler, Ulrike, Ekawardhani, Savira, Dolado, Ignacio, Saliba, Johan A

Journal:

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

17

DARPins: A new generation of protein therapeutics

Michael T. Stumpp, H. Kaspar Binz, Patrick Amstutz

Journal:

Drug Discovery Today

Year:

2008

Language:

english

File:

PDF, 574 KB

english, 2008

18

Engineered proteins as specific binding reagents

H Kaspar Binz, Andreas Plückthun

Journal:

Current Opinion in Biotechnology

Year:

2005

Language:

english

File:

PDF, 383 KB

english, 2005

19

Inhibition of Caspase-2 by a Designed Ankyrin Repeat Protein: Specificity, Structure, and Inhibition Mechanism

Andreas Schweizer, Heidi Roschitzki-Voser, Patrick Amstutz, Christophe Briand, Maya Gulotti-Georgieva, Eva Prenosil, H. Kaspar Binz, Guido Capitani, Antonio Baici, Andreas Plückthun, Markus G. Grütter

Journal:

Year:

2007

Language:

english

File:

PDF, 1.33 MB

english, 2007

20

A novel strategy to design binding molecules harnessing the modular nature of repeat proteins

Patrik Forrer, Michael T. Stumpp, H.Kaspar Binz, Andreas Plückthun

Journal:

Year:

2003

Language:

english

File:

PDF, 189 KB

english, 2003

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